Description
Synergy Mini Vials 4cc (8 x 0.5 cc doses)
Effective Bone Graft Substitute
Perfect for dental applications. Ideal auto or allograft extender.
Radiodense
Clearly evident on radiographic images, allowing visualization of bone graft placement.
Affordable
The price conscious solution for periodontal or orthopedic bone void filling.
Innovative, Convenient Packaging
WHAT IS SYNERGY?
Synergy is an advanced biosynthetic bone graft comprised of calcium phosphates that occur naturally in real bone. It is a biphasic combination of β-Tricalcium Phosphate (β-TCP) and Hydroxyapatite (HA).
FEATURES AND BENEFITS
Advanced Formulation - Biphasic Synergy is composed of biocompatible β-TCP and HA1 sintered together.
The ratio is optimized for swift transformation into new bone throughout the graft.
- 85% resorbable β-TCP
- 15% structurally stable HA
Balanced Remodeling - Synergy works with the body in two integrated phases:
- Phase 1: β-TCP simultaneously resorbs as new bone is formed2, remodeling throughout the graft
- Phase 2: HA microparticles slowly resorb, providing an osteoconductive scaffold
Cancellous-like, osteoconductive morphology - Synergy’s structure is the architectural equivalent of cancellous bone.
- Interconnected porous structure encourages stem cell migration, proliferation and differentiation into osteoblasts2
- Provides for an adequate flow of nutrients to enhance new bone formation3
HOW IT WORKS
These intelligent bioactive materials have the proven ability to stimulate bone formation.3 The β-TCP quickly releases calcium ions,4 that cause clotting and release of platelet-derived growth factors. This cascade of mineral release and blood clotting provides the perfect environment for stimulation of bone healing.
The cancellous-like porosity and surface structure encourage inward cell migration. As the β-TCP resorbs more space is created to support angiogenesis and bone formation1. The micro particles of HA provide a more long lasting osteoconductive structure.
INDICATIONS
Filling, bridging and/or reconstruction of non weight-bearing bony defects.
- Void filling / Extraction sites
- Periodontal pockets / Other bone loss
- Fracture repair
- Cysts &sol/ Other osseous defects
References
1Farina et al., In vivo behaviour of two different biphasic ceramic implanted in mandibular bone of dogs. J Mater Sci: Mater Med 19:1565-1573, 2008
2Spivak JM, Hasharoni A. Use of hydroxyapatite in spine surgery. Eur Spine J. 10: S197-S204, 2001
3Habibovic P, de Groot K. Osteoinductive biomaterials –properties and relevance in bone repair. J Tissue Eng Regen Med. 1: 25-32, 2007
4Daculsi et al., Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization. J Bio Mat Res 23:883-94,1989
